Effectiveness of matching human leukocyte antigens (HLA) in corneal transplantation: a systematic review protocol
نویسندگان
چکیده
Abstract Background Corneal transplantation is the most frequently performed in UK. Despite this, therapeutic value of matching human leukocyte antigen (HLA) subtypes for transplanted corneas remains controversial. Ocular immune privilege was originally deemed to render unnecessary; however, more recently, has demonstrated improved outcomes including graft success, amongst others. This systematic review aims evaluate effectiveness major and minor on corneal transplantation. Methods Standard methodology will be used identify, select extract data from observational studies clinical trials assessing effects HLA outcomes. Bibliographic databases (Cochrane Library, EMBASE, MEDLINE, Web Science, Scopus), trial registers, abstract conference proceedings, addition dissertation, thesis grey literature searched. Neither date publication nor language restricted, non-English articles translated where necessary. The primary outcome assess success different degrees matching/mismatching. precise end measure varies includes rejection, immunoreaction, failure survival. Therefore, extracted across all relevant parameters grouped subsequent statistical tests. Risk bias assessment completed, appropriate each study design. Study selection, extraction risk independently completed by two reviewers. Data tabulated, a narrative synthesis presented. Meta-analysis there sufficient homogeneity between warrant its effective completion. Subgroup sensitivity analysis undertaken if appropriate. Discussion Many have investigated A needed collate analyse this evidence. Findings may form basis evidence-based recommendations pre-operative typing grafts Systematic registration PROSPERO reference CRD42020198882
منابع مشابه
Matching for Human Leukocyte Antigens (HLA) in corneal transplantation - to do or not to do.
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ژورنال
عنوان ژورنال: Systematic Reviews
سال: 2021
ISSN: ['2046-4053']
DOI: https://doi.org/10.1186/s13643-021-01704-7